B-lineage acute lymphocytic leukemia (B-ALL) is the most common childhood malignancy, yet we still do not understand the molecular mechanisms that lead to the genesis of this disease and there are no known strategies for its prevention. Pediatric B-ALL cells deviate from non-leukemic human B cells in the temporal order in which segments of their chromosomal DNA are duplicated (replication timing.
The gopher tortoise (Gopherus polyphemus) is native to the southeastern United States and is considered a keystone species for their roles in ecosystems such as pine savannas, which are highly abundant in Florida. The gopher tortoise is named for it’s burrowing behavior. It digs burrows for shelter, where it is protected from the predators and extreme temperatures. These burrows are used by a number of other species for shelter. The gopher tortoise is classified as a “threatened” species by the U.S.